The aim of the current study was to examine the potential of hyperostosis frontalis interna hfi as a criterion for determining sex and age. This condition is believed to be seen mostly in females. Hyperostosis frontalis interna is a morphological pattern characterized by single or multiple bony nodules situated on the inner lamina of the frontal bone. A 74 year old patient, ew, with dorsolateral frontal cortical compression due to hyperostosis frontalis interna, in the absence of the morgagni or stewartmorel syndromes, is described.
Identifying and classifying hyperostosis frontalis interna. Hyperostosis frontalis interna hfi is a condition that involves thickening of the inner surface of the frontal bone with sparing of the midline. What is hyperostosis frontalis interna diseasemaps. Hyperostosis frontalis interna hfi is a bone condition that mainly affects the inner table of the frontal bone. Well appreciated on the lateral skull radiograph indicated by arrows. Thank you for your interest in spreading the word about the bmj.
A disorder where the front bone of the skull becomes thicker than normal. It has been the topic of occasional discussion and considerable confusion in european writings since its description by morgagni. Hyperostosis frontalis interna radiology reference. Full text full text is available as a scanned copy of the original print version. Hyperostosis frontalis interna in a child with severe. Hyperostosis frontalis interna, causing frontal lobe. Etiopathogenesis of hyperostosis frontalis interna. It is seldom found in males, but it is a common phenomenon among postmenopausal females in. Hci is a unique autosomaldominant sclerosing bone dysplasia affecting the skull base and the calvaria, characterized by cranial nerve deficits due to stenosis of neuroforamina, whereby the mandible is affected to a lesser extent. In most studies an incidence around 10% is reported, with a wide variation between studies because of different criteria and techniques for example. Hyperostosis of the internal table of the frontal bone is not an uncommon phenomenon. The purpose of this case study is to report an unusual case of hyperostosis frontalis interna. Definition of hyperostosis frontalis interna in the dictionary.
Hyperostosis frontalis interna hfi, symmetric thickening of the inner table of the frontal bone, is relatively common in women but very rare in. Hyperostosis frontalis interna hfi is classified into a broad category of hyperostoses termed either hyperostosis cranii diffusa hcd, in which there appears a uniform thickening of all cranial vault bones murczynski, 1952, or hyperostosis calvariae interna hci. Hyperostosis frontalis interna radiology jama neurology jama. Transient diminution of activity was seen on early radionuclide images of the brain in 5 patients with hyperostosis frontalis interna and filled in on subsequent studies.
The pathological process may be bilateral and symmetrical with sessile or nodular thickened areas. Hyperostosis frontalis interna is a disorder marked by benign overgrowth of the inner table of the frontal bone. Hyperostosis frontalis interna associated with hypogonadism in an. It can form part of the triad of morgagni syndrome in the correct clinical setting.
The entity generally referred to as hyperostosis frontalis interna, the morgagni syndrome, or the stewartmorel syndrome, and recently renamed metabolic craniopathy by moore 43 is not new to medical literature. Hyperostosis frontalis interna is characterized by an irregular nodular thickening of the inner table of the skull and at times the diploe of the cranial bones. From a perusal of the literature it would appear that the bony change is often associated with a characteristic clinical syndrome, the recognition of which may lead to a more frequent. The use of pathological conditions in age and sex determination, important factors in personal identification, is not widespread in anthropology and legal medicine. Comparisons of various clinical, endocrine, and metabolic indexes in a nonpatient population with and without hyperostosis frontalis interna showed that those with it were older, heavier, and had thicker skin folds, higher serum triglyceride levels, and a. Thickening of calvarium is noted anteriorly involving the frontal bone. Hyperostosis frontalis interna hfi, first mentioned 1765 by santorini and morgagni in an autopsy case, is characterised by progressive thickening of the inner table of the frontal bone 1. Hyperostosis frontalis interna is an unexplained irregular thickening of the inner table of the frontal bone. It is not clear that this disorder is actually rare. Histology revealed an organized trabecular pattern with overall thickening of the cancellous bone. The progressive bone overgrowth causes entrapment and dysfunction of cranial nerves i, ii, v, vii, and viii waterval et al. A case of extensive hyperostosis frontalis interna in an. The external lamina and the diploe of the bone are usually not affected, but the abnormality may extend to the parietal bones.
Information and translations of hyperostosis frontalis interna in the most comprehensive dictionary definitions resource on the web. In addition to conventional neuropsychological measures ew was administered one nonspatial and two spatial self ordered working memory tasks, as well as a standard measure of fluid intelligence or g. In the evaluation of the ct features of focal hyperostosis, 2 patterns of localized bone thickening were noted. Hyperostosis frontalis interna morgagnistewartmorel. Most of the descriptions hitherto have concerned autopsy specimens. The site of marillac charente, france has yielded an important stratigraphic sequence containing numerous neandertal remains some of them with peri. Pdf hyperostosis frontalis interna, acromegaly and. Hiperostosis frontal interna pdf hyperostosis frontalis interna is characterized by the thickening of the frontal bone of the skull. Hyperostosis frontalis interna in a neandertal from. Imaging features and progression of hyperostosis cranialis. Hyperostosis frontalis interna, acromegaly and hyperprolactinaemia. However, such hyperostosis of the temporal andor sphenoid bone is rarely discussed in the available literature, especially in the absence of meningioma. Scintigraphic findings in hyperostosis frontalis interna.
We report a case of hyperostosis of the frontal, temporal. In 3 patients the changes corresponded extremely well with both modalities. Hyperostosis frontalis interna hfi is a disorder involving progressive symmetric thickening of the inner table of the frontal bone of the human skull. The condition is generally of no clinical significance and an incidental finding. A severe case of hyperostosis frontalis interna and. Current macroscopic classification defines four gradesstages of hfi based on the morphological appearance and size of the affected area. Hyperostosis frontalis interna is an abnormality of the inner table of the frontal bones of the skull consisting of typically smooth, rounded enostoses covered by. Hyperostosis frontalis interna is a morphological feature of the frontal bone that usually presents as single or multiple bilateral nodules on the inner lamina, while most of the diploe and external lamina of the bone remain unaffected. Hyperostosis frontalis interna in a child with severe traumatic. Hyperostosis cranialis interna is a bone disorder characterized by endosteal hyperostosis and osteosclerosis of the calvaria and the skull base. She also had severe, diffuse smallvessel ischemic changes, most severe in the bilateral basal ganglia regions not shown, which probably were the cause of her gait instability, extrapyramidal signs. Hyperostosis frontalis interna the british journal of. Hyperostosis frontalis interna and hyperphosphatasemia. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.
The disorder may be found associated with a variety of conditions such as. Symptoms of hyperostosis frontalis interna including 11 medical symptoms and signs of hyperostosis frontalis interna, alternative diagnoses, misdiagnosis, and correct diagnosis for hyperostosis frontalis interna signs or hyperostosis frontalis interna symptoms. Hyperostosis frontalis interna is found to be associated with many different conditions like seizure disorder. Hypertosis frontalis interna hfi is a condition of unknown etiology characterized by excess bone growth that is manifested on the inner table of the frontal bone. Hyperostosis frontalis interna annals of internal medicine. Pdf the association between hyperostosis frontalis interna hfi, acromegaly and hyperprolactinaemia was investigated.
It is found predominantly in women after menopause and is usually asymptomatic. Pdf hyperostosis frontalis interna is a morphological pattern characterized by single or multiple bony nodules situated on the inner lamina of. Diffuse idiopathic skeletal hyperostosis genetic and. Frontal view of skull on left shows sclerosis in a patchy almost nodular appearance blue arrows which characteristically does not cross the midline black arrow. Increased serum alkaline phosphatase levels were found in about one half of a group of 65 persons with hyperostosis frontalis interna. In this case of severe hyperostosis frontalis interna, the subject was a 77yearold female human donor who had an overwhelming number of comorbidities. Get a printable copy pdf file of the complete article 483k, or click on a page. Hyperostosis frontalis interna is an inherited pathological condition which is characterized by thickening of the frontal bone of the skull. Hyperostosis of the internal table of the frontal bone is an unusual clinical finding. Find out what hyperostosis frontalis interna is and know more about it. The new bone forms most often where ligaments and tendons connective tissues that connect bones join bone entheseal area, but there is also a generalized hardening of bones and bone overgrowth hyperostosis. What is hyperostosis frontalis interna hyperostosis frontalis interna description. Hyperostosis frontalis interna is a common, benign thickening of the inner side of the frontal bone of the skull.
Microarchitectural patterns of hyperostosis frontalis. To describe the clinical and radiological findings in a patient with hyperostosis frontalis interna hfi background. On the lateral view on the right, the hyperostosis is confined to the frontal bone white arrow. Hyperostosis frontalis interna is a benign condition. Although seen frequently during dissections and autopsies, hyperostosis frontalis interna hfi a morphological pattern of the frontal bone thickening is often ignored and its nature and development are not yet understood sufficiently. Hyperostosis frontalis interna hfi is a condition involving limited proliferation of the inner table of the frontal bone, which may be accompanied by endocrinopathies e.
Hfi is characterized by presence of multiple nodules along the inner lamina of the frontal bones. Mostly frequently it is found as an incidental finding discovered during an xray or ct scan of the skull additional images. Hyperostosis frontalis interna morgagni stewartmorel. While people with morgagnistewartmorel syndrome nearly always have hyperostosis frontalis interna, hyperostosis frontalis interna is usually an incidental finding on xray films, computed tomography, or magnetic resonance imaging of the head and by itself is not indicative of any disease.
The aim of this study is to describe the specific radiologic characteristics and course of the disorder. Hyperostosis frontalis interna, a genetic disease two. Deficits on self ordered tasks associated with hyperostosis frontalis. Pdf etiopathogenesis of hyperostosis frontalis interna. Hyperostosis frontalis interna is characterised by benign overgrowth of the inner table of the frontal bone. In hci, endosteal hyperostosis occurs in the parietal, frontal, occipital, sphenoid, ethmoid, and temporal bones without obliteration of the diploe. Hyperostosis frontalis interna hfi is an overgrowth of bony tissue located in the inner aspect of the frontal bone fig. Hyperostosis frontalis interna is characterized by benign overgrowth of the inner table of the frontal bone. Hyperostosis definition of hyperostosis by medical. Estimation of sex and age in skeletons is essential in anthropological and forensic medicine investigations. Abstract hyperostosis frontalis interna hfi is manifested by the accretion of bone on the inner table of the frontal bone. Hyperostosis corticalis generalisata, or van buchem disease, is a recessively inherited variety of endosteal hyperostosis, characterized by progressive mandibular enlargement from childhood, and in adult life by signs and symptoms resulting from sclerotic encroachment of optic and acoustic foramina. Hyperostosis frontalis interna symptoms, diagnosis.
Get a printable copy pdf file of the complete article 1. We present here a case of hfi in a female cranial vault found in the temple of. More detailed information about the symptoms, causes, and treatments of hyperostosis frontalis interna is available. The entity generally referred to as hyperostosis frontalis interna, the morgagni syndrome, or the stewartmorel. It is typically bilateral and symmetrical, and may extend to involve the parietal bones. Diffuse idiopathic skeletal hyperostosis dish is a common skeletal disorder characterized by unusual, new bone formation. The most marked change is thickening of the inner table of the calvaria, except for the parietal region, where broadening of the diploe is more explicit. The association between hyperostosis frontalis interna hfi, acromegaly and.
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